作　　者： ; ; ; ;

机构地区： 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室

出　　处： 《安徽农业科学》 2009年第8期3561-3563,共3页

摘　　要： β-防御素在黏膜上皮细胞广泛表达,在先天免疫系统中扮演重要角色。因具有独特的抗菌机制和广谱抗细菌、抗真菌、抗病毒活性。极难产生抗药性而日益受到人们的关注。就β-防御素的分子特征、生物学活性、抗菌机理、基因重组表达,目前科研中存在的问题及其应用前景做了综述,为临床医学提供参考。 β-defensins, which are wildly expressed by epithelial cells, take an important role in the innate immune system. Because of their broad-spectrum of antimicrobial activity and defense against positive and negative Gram＇s bacteria, epiphyte, protozoan and enveloped virus, in additional, β-defensins have distinctive antibacterial mechanism, and hardly no-endurance to drug, so the research on β-defensins has become a hot spot in the world. This study gave the β-defensins a brief description about its molecular structure, bioactivity, functionary mechanism and recombinant gene expression, and put forward some problems in the current research and application.

关 键 词： 防御素 生物学活性 抗菌机理 重组表达 应用

领　　域： [农业科学] [农业科学]