作　　者： ; ; ; ; ;

机构地区： 安徽理工大学化学工程学院

出　　处： 《安徽理工大学学报（自然科学版）》 2009年第1期27-30,共4页

摘　　要： 为得到抗菌活性优异的化合物,通过首先分别合成5-溴水杨醛和2,3,4,6-O-四乙酰基-α-D-溴代葡萄糖,随后经DMAP催化糖苷化和甲醇钠-甲醇碱性水解等反应步骤,成功合成5-溴水杨醛-O-β-D-葡萄糖苷。利用1H NMR,13C NMR,IR,GC-M S等对所合成的目标化合物及中间体进行了结构表征。 In order to obtaine compounds with good antibacterial activity, 5-bromosalicylaldehyde-O-β-D-glucoside was synthesized by the following process： 5-bromosalicylaldehyde and 2, 3, 4, 6-O-te- traacetyl-α-D-glucopyranosyl bromide were synthesized seperately and then followed by O-glycosylation with DMAP as a catalyst and hydrolysis in aqueous solution with CH3ONa-CH3OH. Structures of the target compound and intermediates were characterized by ^1H NMR,^13C NMR, IR and GC-MS.

关 键 词： 溴水杨醛 糖苷 合成

领　　域： [理学] [理学]