作　　者： ; ; ; ;

机构地区： 华南理工大学生物科学与工程学院

出　　处： 《中山大学研究生学刊（自然科学与医学版）》 2008年第4期1-6,共6页

摘　　要： RAS是维持机体血压和电解质平衡的内分泌系统,近年来,研究发现RAS的成分都能在脂肪组织中表达,且ANGⅡ作为脂肪分化与代谢的营养因子。本文分析脂肪组织中血管紧张素原与肥胖和高血压的关联,综述了血管紧张素Ⅱ对脂肪细胞细胞分化代谢的影响及调节机理,探讨RAS对肥胖性高血压形成的影响。分析表明RAS对肥胖性高血压具有一定的诱导作用,且其对肥胖的诱导大都由AT1R介导,同时AT1R和AT2R对肥胖的形成也具有拮抗作用。从而对肥胖性高血压的病理机制的探索以及治疗提供新思路。 The RAS been recognized as an important regulator of systemic blood pressure and electrolyte balance, recently, some data have been accumulated in support that RAS is produced in adipose tissue, AnglI is a most important factor contribute adipose tissue in the process of adipogenic differentiation and in the regulation of body weight in renin-angiotensin system. In this review, describe the relationship between AGT and hypertensive subjects with obesity, and the role of the adipose tissue ANGII in the process of adipogenic differentiation. The writer detail the differential regulation of the adipose tissue ANGII in obesity and hypertension. The results shows that the involvement of AT1 receptors in preadipocyte differentiation induction by RAS. The writer also detail the differential regulation of the adipose tissue renin-angiotensin system in obesity and hypertension and thereby also speculate on its possible role in the development of obesity-associated hypertension.

关 键 词： 肾素 血管紧张素系统 脂肪组织 高血压 肥胖

领　　域： [农业科学] [农业科学] [自动化与计算机技术] [自动化与计算机技术]