作　　者： ; ; ;

机构地区： 贵州大学

出　　处： 《武汉理工大学学报》 2008年第12期80-84,共5页

摘　　要： 通过γ-氯丙基三甲氧基硅烷的偶联,将水溶性聚乙烯亚胺(PEI)接枝在纳米SiO2表面,随后分别用1-溴己烷和碘甲烷对接枝的PEI进行N-烷基化修饰,使PEI中的部分氨基转变成季铵盐,得到水不溶性MQAS/SiO2微粒。抗菌检测表明,接枝的PEI分子量越大,MQAS/SiO2微粒的抗菌效果越好。MQAS/SiO2微粒经甲基化修饰后,季铵盐含量由0.96%增加到3.37%,其抗菌性能显著增强。对MQAS/SiO2微粒进行多次彻底洗涤,其抗菌性能并没有下降。 Water-soluble polyethylenimine （PEI） was grafted onto the surface of Nano-SiO2 particles through the couple effect of γ-chloropropyltrimethoxysilane, and the water-insoluble MQAS/SiO2 containing macromolecular quaternary ammonium salts was prepared followed by the N-alkylation of coated PEI with 1-bromohexane and idomethane, respectively. The antimicrobial assay demonstrates that the higher molecular weight of PEI was grafted, the better bactericidal activity of the MQAS/ SiO2 would achieve. Compared to the MQAS/SiO2 without methylation, the amount of quaternary ammonium salts in the methylated MQAS/SiO2 was added from 0.96 % to 3.37 %, and its antimicrobial activities against bacteria and yeast were enhanced obviously. The bactericidal activities of the exhaustively washed MQAS/SiO2 did not decline compare to their counterparts without washing.

关 键 词： 聚乙烯亚胺 非缓释 季铵盐 抗菌

领　　域： [化学工程] [理学] [理学]