机构地区: 华东理工大学化学与分子工程学院结构可控先进功能材料及其制备教育部重点实验室
出 处: 《催化学报》 2008年第9期878-880,共3页
摘 要: 以2-氯-4,6-二硝基-1,3-苯二酚为原料,丙酮为烷基源,氢气为还原剂,研究了在10%Pd/C催化剂上一锅法合成N-单烷基氨基苯酚化合物4,6-二(异丙基氨基)-1,3-苯二酚的反应工艺.考察了反应条件如醋酸量、丙酮浓度、氢气压力、催化剂量和反应时间对反应的影响,开发出一条高收率、高选择性制备N-单烷基氨基苯酚化合物的合成路线. 2-Chloro-4,6-dinitrobenzene-1,3-diol was catalytically converted to the corresponding N-alkyl secondary aminophenol, 4,6-10is(isopropylamino)henzene-1,3-diol, in high yield by one-pot operation using acetone as alkyl source and hydrogen as reducing reagent over the 10 % Pd/C catalyst. The effects of reaction conditions such as the amount of acetic acid, acetone concentration, hydrogen pressure, catalyst amount, and reaction time on the selectivity for 4,6-bis(isopropylamino) benzene-1,3-diol were investigated.