作　　者： ; ; ; ; ; ;

机构地区： 江苏大学临床医学院

出　　处： 《细胞生物学杂志》 2008年第4期457-461,共5页

摘　　要： 跨膜受体可从膜表面进入细胞核内直接调控细胞的生命活动,但其核转位的途径至今尚无定论。已有多种模型分析了跨膜受体的核转位过程,它们均强调受体必须从细胞膜或内吞泡"逃脱"到细胞质后,才能进入细胞核内。然而,内吞-分选-浓缩-膜泡融合-释放模型却诠释了一条不同的跨膜受体核转位通路,这将有利于进一步阐明跨膜受体核转位的模式及其分子机制,并为核靶向药物的开发、目的基因的导入、病毒感染的治疗等应用研究提供新的策略。 Although transmembrane receptors from cell surface to nucleus can generally regulate the cellular life activities, their pathways of nuclear translocation still remain to be elucidated. Several modes have been suggested to explain the pathways of nuclear translocation of transmembrane receptors, which all emphasize that transmembrane receptors could translocate into nuclues following ‘escape＇ from cell membrane or enodsomes into cytoplasm. Herein, a novel nuclear translocation pathway of transmembrane receptors is.hypothesized as an endocytosis-soning-concentration-fusion-translocation pathway model. It is helpful to understand the molecular mechanism of transmembrane receptors＇ nuclear translocation, and provide a promising research approach toward biomedicine and biotechnology, such as drugs target, gene therapy, gene engineering, and virus infection.

关 键 词： 跨膜受体 核转位 信号转导 内体 融合

领　　域： [生物学] [生物学]