作　　者： ; ; ; ; ;

机构地区： 皖西学院化学与生命科学系

出　　处： 《癌变．畸变．突变》 2008年第2期157-159,共3页

摘　　要： 背景与目的:研究蕨菜黄酮提取物的急性毒性与潜在致突变性。材料与方法:采用小鼠经口急性毒性试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验。结果:蕨菜黄酮提取物小鼠经口的LD50>20.0g/kg,小鼠骨髓细胞微核试验以及精子畸形试验结果均为阴性(P>0.05)。结论:本实验条件下,蕨菜黄酮提取物的经口LD50>20.0g/kg,属无毒级,未见有致突变作用。 BACKGROUND AND AIM： To study the acute toxicity and the mutagenicity of the flavonoids extracted from pteridium aquilinum var. latiusculum. MATERIALS AND METHODS： The oral acute toxicity test, micronucleus test of bone marrow PCE cell and sperm shape abnormality test were carried out. RESULTS： LD50 of the flavonoids extracts from pteridium aquilinum var. latiusculum in rats was more than 20.0 g/kg. The micronucleus rates and sperm abnormality rates in all doses were negative（P〉 0.05） CONCLUSION： The flavonoids extracted from pteridium aquilinum var. latiusculum was considered a substance with no toxicity and mutagenic activity in this study.

关 键 词： 蕨菜 黄酮 急性毒性 微核 畸形

领　　域： [轻工技术与工程] [轻工技术与工程]