机构地区: 中国海洋大学海洋生命学院海洋生物系
出 处: 《中国海洋大学学报(自然科学版)》 2008年第1期89-94,共6页
摘 要: 在不同来源降钙素中,鲑鱼降钙素的活性最高,在钙的代谢和治疗骨质疏松、Paget氏综合症、高钙血症等疾病中有巨大的药用价值。其C末端的酰胺化对它完整的生物活性起重要作用。本文综述了鲑鱼降钙素基因在大肠杆菌、链霉菌、乳酸杆菌和蓝藻等原核细胞,在酵母、昆虫、动植物等真核细胞中异源表达的研究进展,以及通过基因工程的方法能够改进生物表达系统,提高鲑鱼降钙素活性的动态。 Salmon calcitonin, an endogenous polypeptide hormone, plays an important role in both calcium homeostasis and bone remodelling. The amidation of C-terminal is crucial for its full biological activity. Here we summarize the progress of salmon calcitonin's heterogenous expression in prokaryotic and eukaryotic expression systems as well as the amidation of C-terminal. Both the biological activity of salmon calcitonin and the biologic expression system can be improved by genetic engineering techniques.