作　　者： ; ; ; ;

机构地区： 中国林业科学研究院林产化学工业研究所国家林业局林产化学工程重点开放性实验室

出　　处： 《林产化学与工业》 2007年第6期81-84,共4页

摘　　要： 以去氢枞酸为原料,经过磺化得到磺化去氢枞酸,再与金属盐直接反应合成出多种磺化去氢枞酸盐;用IR对产物进行了表征;研究了金属盐直接反应法制备不同磺化去氢枞酸盐的反应体系的最佳pH值;确定了用于抗胃酸活性的磺化去氢枞酸盐的种类。对磺化去氢枞酸亚铁盐进行了毒理学和病理学测试,测试结果显示该亚铁盐基本无毒,用药量分别为50、100、200 mg/kg时,胃酸量和总胃酸抑制率效果均比阳性药西咪替丁用药量为160 mg/kg时好。 Several sulfodehydroabietates were prepared via sulphonation and salt reaction using dehydroabietic acid directly as raw material. The structures were characterized by IR. One-step salt reaction was studied in detail, especially the effect of pH value of system, which is the critical factor. The optimum pH values of different systems were obtained by simulating reaction and comparing to theoretical pH value of generating precipitation. According to body pH value and toxicity, ferrous iron, cobalt, nickel and manganese salts were selected for synthesizing sulfodehydroabietates, which are resistant to gastric juice activity. The pathology and toxicology of dis-ferrous sulfodehydroabietate were studied. The results showed that the toxicology is very low, the inhibition to gastric secretion and inhibition ratio of total acid by ferrous sulfodehydroabietate at 50, 100, 150 mg/kg doses respectively are better than that of cimitldine at 160 mg/kg dose.

关 键 词： 磺化去氢枞酸 亚铁松香酸盐 抗胃酸 西咪替丁

领　　域： [化学工程]