机构地区: 杭州师范学院材料与化学化工学院有机硅化学及材料技术教育部重点实验室
出 处: 《有机化学》 2007年第4期483-487,共5页
摘 要: 在100℃,无外加溶剂条件下,离子液体功能化二氧化硅催化一系列芳醛和活泼亚甲基化合物进行Knoevenagel缩合反应,以高产率生成相应产物.当反应底物为水杨醛与氰基乙酸乙酯的时候,产物为3-乙氧基羰基香豆素,这是水杨醛和氰基乙酸乙酯缩合关环,再发生氰基醇解的产物.采用离子液体功能化二氧化硅作为反应催化剂,反应后催化剂可回收再利用. The Knoevenagel condensation of a series of aromatic aldehydes with active methylene compounds proceeded smoothly in the presence of catalytic amounts of ionic liquid functionalized SiO2 at 100℃ without any additional volatile organic solvents, and the desired alkenes were obtained in good purity with excellent yields. In particular, when the Knoevenagel condensation of 2-hydroxybenzaldehyde was conducted with ethyl 2-cyanoacetate, 3-ethoxycarbonylcoumarin was obtained by simultaneous cyclization and alcoholysis of cyanide. In addition, the catalyst can be used recyclably.