作　　者： ; ; ;

机构地区： 中国林业科学研究院林产化学工业研究所国家林业局林产化学工程重点开放性实验室

出　　处： 《林产化学与工业》 2007年第2期97-99,共3页

摘　　要： 用直接缩合法合成了含氟的取代苯甲醛缩脱氢枞胺Schiff碱,用IR、1HNMR光谱确证其结构。对含氟Schiff碱进行体外抑菌活性试验。结果表明,含氟的取代苯甲醛缩脱氢枞胺Schiff碱对金黄色葡萄球菌和枯草芽孢杆菌等多种细菌有较强的抑制作用。对氟苯甲醛缩脱氢枞胺Schiff碱对金黄色葡萄球菌以及枯草芽孢杆菌的抑制作用最强,抑菌圈直径分别达到1.65和1.30cm;氟的引入对大肠杆菌无效,抑制能力反而降低。 Fluorine-containing substituted benzaldehyde semi-dehydroabietylamine Schiff bases were synthesized by direct condensation, and their structures were characterized by IR and ^1H NMR spectroscopy. The antibacterial activities of fluorine-containing Schiff bases were tested by extracorporeal experiments. It has been found that fluorine-containing substituted benzaldehyde semi-dehydroabietylamine Schiff bases displayed strong antibacterial activities against many kinds of bacteria such as Staphylococcus aureus and Bacillus subtilis, p-F-substituted benzaldehyde semi-dehydroabietylamine Schiff base has the strongest activity against S. aureus, and B. subtilis. The diameters of antibacterial rings reached 1.65 and 1.30 cm, respectively. The introduction of fluorine atom in Schiff base was ineffective against Escherichia coli, the activity was even reduced.

关 键 词： 取代苯甲醛缩脱氢枞胺 含氟 碱 抑菌活性

领　　域： [化学工程]