作　　者： ; ; ; ; ;

机构地区： 广州体育学院运动与健康系广东省高教厅运动生化重点实验室

出　　处： 《广州体育学院学报》 2007年第2期111-115,共5页

摘　　要： 目的:探讨间歇低氧训练对抗氧化酶系统及其适应能力的影响,为运动与低氧适应的研究提供理论依据。方法:SD大鼠70只,随机分为7组,分别为常氧安静组(NC)和常氧训练组(NT);急性低氧安静组(AHC)、急性低氧运动组(AHE)和急性低氧训练组(AHT);间歇低氧安静组(IHC)和间歇低氧训练组(IHT),分别测定大鼠心肌、肝脏和骨骼肌组织细胞液和线粒体的SOD、GSH-Px和CAT的活性。结果:急性低氧运动应激后,大鼠SOD、GSH-Px和CAT活性均有升高的趋势。其中心肌和骨骼肌细胞浆的CuZnSOD活性显著性上升;心肌和骨骼肌线粒体MnSOD显著性上升;肝脏和骨骼肌细胞液和线粒体GSH-Px显著性上升。经过四周的间歇低氧训练后SOD、GSH-Px和CAT活性不同程度提高,心肌和骨骼肌线粒体MnSOD、心肌和肝脏线粒体GSH-Px活性显著性升高。结论:低氧运动能使抗氧化酶活性上升,其中急性低氧运动酶活升高的现象是机体代偿性变化,是机体自我保护的表现;而间歇低氧训练酶活升高是机体产生适应性变化的结果。 Objective： To study the effects of intermittent hypoxic training on antioxidant enzyme system and adaptive capacity, the theory of exercise and hypoxic acclimatization is provided. Methods： 70 SD rats were randomly divided into 7 groups： control group （NC）, training group （NT）, acute hypoxic group （AHC）, acute hypoxic exercise group（AHE）, acute hypoxic training group（AHT）, intermittent hypoxic group（IHC）, intermittent hypoxic training group（IHT） . SOD, GSH - Px and CAT activity of cytoplasm and mitochondria in rat the heart , liver and skeletal muscle are assessed. Results： SOD, GSH - Px and CAT activity of cytoplasm and mitochondria in rat increased by hypoxic stress. SOD activity of cytoplasm in rat the heart and skeletal muscle increased more significandy, as well as mitochondria in rat the liver and skeletal muscle; GSH - Px activity of cytoplasm and mitochondria in rat liver and skeletal muscle increased more significantly. After 4 - week intermittent hypoxic Training, SOD,GSH - Px and CAT activity somewhat increased, mitochondria SOD in rat the heart and skeletal muscle together with GSH - Px in the heart and liver increased more significantly. Conclusion： Antioxidant enzyme activity increased during hypoxic exercise, acute hypoxic exercise increasing enzyme activity attributed to protection by it-serf in organism; and acute hypoxic training increasing enzyme activity attributed to adaptation of hypoxia and training.

关 键 词： 间歇低氧训练 适应能力

领　　域： [文化科学] [文化科学]