作　　者： ; ; ; ;

机构地区： 北京大学

出　　处： 《中国生物化学与分子生物学报》 2007年第3期177-180,共4页

摘　　要： 大多数正常体细胞有有限的复制周期,并最终进入生长停滞状态被称为复制性衰老.迄今比较公认的3条细胞衰老信号转导途径是:p16INK4a/Rb、p19ARF/p53/p21Waf1以及PTEN/p27.目前发现,在基因转录水平上,有些转录因子的结构域对调节p16INK4a、p53/p21Waf1以及p27等与细胞衰老相关基因的表达有重要作用,如E2DBD、环指域(RINGfinger)等;其次,各条通路要发挥作用,必然要借助其上下游蛋白质的相互作用,其中结构域发挥了纽带作用.本文对其中某些蛋白质相互作用的结构域进行了描述.最后,还总结了其他一些参与细胞衰老的结构域. Most normal somatic cells possess a limited proliferative lifespan after which they enter into a state of terminal growth arrest known as replicative senescence. Three putitive signaling pathways related to cell replicative senescence are p^16INK4n/Rb、p19^ARF/p53/p21^wafl and PTEN/p27 There are some new observations recently. Firstly, in the gene transcription level, the domains of certain transcription factors play important roles in the gene expression such as p^16INK4n,p53/p21^wafl and P27, for example, E2DBD, RING finger and so on. Secondly, activation of each pathway must rely on the protein interactions between its upstream and downstream components in which the protein domains are the key factor. Some of these domains are described here ; in the end, other protein domains related to cell senescense are summarized.

关 键 词： 细胞衰老 信号转导途径 结构域

领　　域： [生物学]