机构地区: 中国科学院长春应用化学研究所
出 处: 《计算机与应用化学》 2007年第1期45-48,共4页
摘 要: 为了DNA一级序列的相似度计算,本文比较了三种编码方案:单一碱基在DNA序列中的相对位置、二联码即相邻二碱基在序列中的相对位置、编序单一碱基在DNA序列中的相对位置和二联码在序列中的编序相对位置,在此基础上,运用分子连接性指数计算得到序列的不变量,进而,由塔尼莫特法计算得到物种间的相似度。由单一碱基在DNA序列中的相对位置法比较相似度,对于本研究中10个物种,得到了与生物进化树非常相一致的结果。 For the similarity comparisons of DNA primary sequences, three coding schemes for DNA primary sequences have been observed. These three schemes are: the relative positions of a single nucleic acid base in a DNA sequence, the relative positions of adjacent pairs of bases; the relative positions coded with a natural number of a single nucleic acid base in' a DNA sequence and the relative positions coded with a natural number of adjacent pairs of bases. Based on the above results, the molecular connectivity indices as sequence invariants were calculated. The method of Tanimoto coefficient was used for the similarity comparisons between ten DNA sequences belonging to β-globin gene in different species. The results agree with the phylogenetic tree satisfactory.
领 域: [生物学]