作　　者： ; ;

机构地区： 中山大学生命科学学院生物系

出　　处： 《水生生物学报》 1996年第4期340-344,共5页

摘　　要： 本文研究了儿茶酚胺类药物对草鱼生长激素水平的影响。腹腔注射儿茶酚胶合成抑制剂α－甲基－对－酪氨酸（α－ＭＰＴ，５μｇ／ｇｂ·Ｗ和５０μｇ／ｇ·ｂＷ）显著降低草鱼鱼种血清生长激素水平，腹腔注射儿茶酚胺能神经毒素６－羟多巴胺（６－ＨＯＤＡ，５μｇ／ｇｂ·Ｗ和５０μｇ／ｇ·ｂｗ也显著降低草鱼鱼种血清生长激素水平。阿卟吗啡（ＡＰＯ，７．１ｍｇ／Ｋｇｂ·ｗ和１２．５ｍｇ／Ｋｇ·ｂｗ）通过背大动脉插管注入草鱼体内后能显著提高草鱼血浆生长激素水平．腹腔注射去甲肾上腺素（ＮＥ，５０ｕｇ／ｇｂ·ｗ）２ｈ，６ｈ和２４ｈ后，草鱼鱼种血清生长激素水平明显低于对照组（ＶＥＨ）；腹腔注射β－肾上腺素能受体拮抗剂Ｐｒｏｐｒａｎｏｌｏｌ（５ｕｇ／ｇｂ·ｗ）或α－肾上腺素能受体增强剂Ｃｌｏｎｉｄｉｎｅ（５ｕｇ／ｇｂ·ｗ）对草鱼鱼种血清生长激素水平无显著影响，而同时注射ＮＥ＋Ｃｌｏｎｉｄｉｎｅ（５０μｇ／ｇｂ·ｗ，５μｇ／ｇｂ·ｗ）或ＮＥ＋Ｐｒｏｐｒａｎｏｌｏｌ（５０μｇ／ｇｂ·ｗ，５μｇ／ｇｂ·ｗ）２ｈ和６ｈ后，草鱼鱼种血清生长激素水平显著高于单独注射ＮＥ（５０μｇ／ｇｂ·Ｗ）的草鱼鱼种．结果表明：儿茶酚胺类药物也参与草鱼生长激素分泌的调节? The effects of catecholamines on the growth hormone (GH) secretion in grass carp,were investigated. α-MPT (i. p, 50ug/gb w and 5ug/gb w) decreased significantly the GH levels in the serum of grass carp fingerling 6 hours post injection. 6 HODA of higher dose (i. p, 50ug/gb w) decreased significantly the GH levels in the fingerlings 2 hours and 6 hours post injection, whereas 6 HODA of lower dose (i. p, 5ug/ gb w) decreased significantly the GH levels in the fingerlings 2 hours post injection. APO (via dorsal aorta cannulae, 7.1 mg / Kgb w and 12.5ing/Kgb w) increased significantly the serum GH levels. NE (i. p, 50ug/gb w) decreased significantly the GH levels in the serum of the fingerlings 2 hours, 6 hours and also 24 hours post injection. Intraperitoneal injections of β adrenergic antagonist Propranolol (5 ug/ gb w) or α adrenergic agonist Clonidine(5ug/ gb w) did not imposed any significant influences on the GH levels in the serum of the grass carp fingerling. The GH levels in the serum of grass carp fingerling injected i. p. with NE+Clonidine (50ug/gb w, sug/gb w) or NE+Propranolol (50ug/gb w, 5ug/gb w) were significantly higher than those injected with NE (50ug/gb w) alone. It is indicated that catecholamines may be involved in the regulation of GH secretion in grass carp, and that NE can bind the β adrenergic receptors to inhibit GH secretion, and bind the α adrenergic receptors to stimulate GH secretion in grass carp fingerling.

关 键 词： 草鱼 草鱼鱼种 生长激素 儿茶酚胺

领　　域： [农业科学] [农业科学] [农业科学] [农业科学]