作　　者： ; ;

机构地区： 暨南大学生命科学技术学院化学系

出　　处： 《广州化工》 1996年第4期6-10,共5页

摘　　要： 本文报导了从猪胆中提取的胆红素与锰、钴、铜、锌的醋酸盐和氯化亚锡、二氯二甲基锡等分别在不同条件下,在CHCl_3或DMF溶剂中合成的一系列金属配合物固体.对它们进行了元素分析、红外、紫外、差热、质谱等表征.着重讨论了它们的分子组成和配位结构.研究发现:胆红素对金属离子的配位表现出多样性,由于胆红素分子本身结构的异构化和金属离子性质的不同.它们的结构随金属离子不同而异,既可以形成1:1(摩尔比)的类卟啉配合物,也可以形成1:2的双核配合物.在合成的一系列胆红素配合物中,除胆红素二甲基锡可以溶于DMF等有机溶剂外,其余配合物均难溶于水、乙醇、三氯甲烷、DMF等溶剂. It is reported that a series of metal - bilirubin complexes were synthesized by the reaction of bilirubin extracted from pig's chola with Mn (AC)_2, Co(AC)_2, Cu(AC)_2, Zn(AC)_2 and SnCl_2, Sn(CH_3)_2Cl_2, etc. at different conditions in CHC1_3 or DMF.These complexes were characterized by elementary analysis, IR, UV - Vis, MS and differential thermal analysis. Their molecular composition and coordination Structure were especially studied. It is found that the coordination reaction of bilirubin with metal ions was mutiplicity, and because of the isomerization of the molecular structure of BR itself and the differences of the metal ions properties, their structures appear to change with different metal ions. Bilirubin can coordinated with metal ions to form either metallo-porphyrinoide or bimetal - bilirubin complexes. Except tin - dimethyl - bilirubin can dissolve in DMF, others of metal - bilirubin are insoluble in water, alcohol, chloroform and DMF.

关 键 词： 胆红素 金属络合物 合成 配位 结构

领　　域： [理学] [理学] [化学工程]