作　　者： ; ; ;

机构地区： 温州医学院环境与公共卫生学院

出　　处： 《汕头大学学报（自然科学版）》 2006年第4期51-56,共6页

摘　　要： 研究罗非鱼暴露在苯并[a]芘(B[a]P)后,其肝脏3种抗氧化酶——超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPx)——活性的剂量时间效应.结果显示,SOD和CAT都表现出在暴露初期被迅速抑制,然后诱导,再被抑制的反应模式,并且CAT对污染的胁迫反应比SOD更加敏感,二者均是B[a]P污染的良好标志物.相比之下,GPx的胁迫反应不明显,长时间暴露在高剂量下才表现出诱导趋势,并不适合于短时间暴露下单独用来作为污染监测的生物标志物. The effect of B[a]P on antioxidant defense system in the liver of juvenile hybrid tilapia （Oreochromis niloticus X O. aureus）was evaluated in this study, including SOD, CAT, and GPx after exposing the fish to B[a]P of 7 doses for various time periods. The activities of both SOD and CAT dccreased initially after a short period of exposure, and increased, but decreased at last. But CAT responded faster, and is more sensitive than SOD at lower dosage. Both SOD and CAT couht be used as sensitive biomarkers for B[a] P toxicity studies. GPx activity varied among the test, and a distinct response to B[a]P treatment was delayed to day 7 in the highest eonce.ntration, thus it was not considered as a suitable biomarker for acute： toxicity studies for B[a]P effects.

关 键 词： 苯并 芘 罗非鱼 抗氧化防御系统 超氧化物歧化酶 过氧化氧酶 谷胱甘肽过 氧化物酶

领　　域： [环境科学与工程]