作　　者： ; ; ; ;

机构地区： 中国科学院生物物理研究所

出　　处： 《生物化学与生物物理进展》 2006年第10期940-941,共2页

摘　　要： 蛋白质异常修饰导致错误折叠的机制目前尚不清楚.提出如下设想:细胞内的蛋白质分子可能发生多种异常修饰,引起蛋白质选择性错误折叠和聚积而导致神经退行性疾病. Although the relationship between abnormal chemical modification and protein misfolding has been widely studied, most work is focused on the effect of a single factor on the structure and function of a protein. Here, it is proposed that a combination of multiple factors may modify selected proteins in vivo, and lead to their misfolding and aggregation in certain cell types.

关 键 词： 蛋白质异常修饰 蛋白质错误折叠 神经退行性疾病 选择性错误折叠

领　　域： [生物学]