作　　者： ; ; ; ; ;

机构地区： 陕西科技大学资源与环境学院

出　　处： 《陕西科技大学学报（自然科学版）》 2006年第4期4-7,16,共5页

摘　　要： 在反相乳液体系中合成了载药淀粉微球,分析了微球的结构特征。分别制备了碳糊电极和淀粉微球修饰碳糊电极,选择具有多个羟基和烯醇结构的抗坏血酸为模型药物。以pH=6.4的磷酸盐缓冲液为底液,支持电解质KCl浓度为0.1 mol.L-1。逐次降低抗坏血酸的浓度,测定不同电极的检测下限。选用1.0×10-4mol.L-1的抗坏血酸溶液,在-0.4 V^0.9 V的电位范围内以50 mV.s-1的速度扫描,记录A^V图。通过比较不同工作电极作用下抗坏血酸的氧化特征,可以推论淀粉微球对抗坏血酸的富集作用更多的依赖于微球结构中的-OH、-NH2与抗坏血酸分子中-OH之间的氢键缔合作用。 The drug-carried starch microspheres were synthesized in reversed phrase emulsion system, and the structure characteristics were analyzed. We also prepared respectively a carbon paste electrode and a carbon paste electrode modified with starch microspheres, and selected ascorbic acid with hydroxyls and enol structure as a model drug. The basal medium consists of pH=6.4 phosphate buffer solution and 0.1mol·L^-1 supporting electrolyte KCl.The lower limits of detection of various electrodes were made certain by decreasing gradually the concentration of ascorbic acid. The solution of 1.0×10^-4mol·L^-1 ascorbic acid was mensurated at scanning speed of 50 mV·s^-1 in range of voltage from-0.4 V to 0.9 V, and the scanning was chalked up. It can be deduced that the enrichment of starch microspheres to ascorbic acid depends mostly on association reaction of hydrogen bond between hydroxyls and amidos of starch mierospheres and hydroxyls of ascorbic acid after contrasting the oxidation features of ascorbic acid when using various electrodes.

关 键 词： 修饰碳糊电极 淀粉微球 抗坏血酸 吸附机理

领　　域： [理学] [理学]