作　　者： ; ; ; ;

机构地区： 武汉大学人民医院

出　　处： 《临床检验杂志》 2006年第4期292-294,共3页

摘　　要： 目的探讨L-选择素P213S基因多态性与心绞痛的相关性。方法用聚合酶链反应．限制性片段长度多态性（PCR．RFLP）技术检测138例心绞痛病患者和156例正常对照者L-选择素基因型，结合血脂水平探讨两者之间的相关性。结果L-选择素基因型PP、Ps和SS频率在心绞痛组和对照组间分别为60．1％、36．3％、3．6％和44．9％、48．1％、7．0％；等位基因P、S频率在心绞痛组和对照组分别为78．3％、21．7％和68．9％、31．1％，两组和对照组间差异均有显著性（P〈0．05）。P等位基因患心绞痛的风险是S等位基因的1．624倍（OR=1．624，95％CI：1．118～2．359）。结论L．选择素P213S基因多态性与心绞痛的发病有相关性，P等位基因可能是心绞痛发病的危险因素之一。 Objective To explore the association between L-selectin gene P213S polymorphism and angina pectoris. Methods L-selectin gene P213S polymorphism in 138 patients with angina pectoris and 156 controls was detected by polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP）. The relationship between gene polymorphism of L-selectin and levels of serum lipids were also studied. Results L-selectin genotype frequencies of PP,PS,SS were 60.1% ,36.3% ,3.6% and 44.9% ,48.1% ,7.0% in angina pectoris group and control group respectively. Allele frequencies of P,S were 78.3% ,21.7% and 68.9% ,31.1% in angina pectoris group and control group respectively. There was significant differences of frequencies of genotype and allele of L-selectin P213S polymorphism between angina pectoris group and control group（ P 〈 0.05 ）. The relative risk of suffering from angina pectoris in P allele carrier was 1. 624 times of S genotype （OR = 1. 624,95% CI：1. 118 -2. 359）. Conclusions L-selectin gene P213S polymorphism associated with angina pectoris. P allele may be a risk factor for angina pectoris in Chinese population.

关 键 词： 选择素 心绞痛 基因多态性

领　　域： [生物学]