作　　者： ; ; ;

机构地区： 上海中医药大学附属曙光医院

出　　处： 《中国中医骨伤科杂志》 2006年第3期4-8,共5页

摘　　要： 目的:探寻腰椎间盘突出症电针镇痛的有效方法,探讨其促循环作用机制。方法:将98例患者按入组先后随机分成治疗组(n=53)与对照组(n=45),观察电针前后疼痛程度以及外周血TXB2、6-K和T/K比值的变化,治疗组采用局部单穴电针,对照组采用常规取穴电针,各组的电针参数与针刺频度一致。结果:两组治疗后患者疼痛程度均明显减轻,但存在着组间差异;同时两组外周血TXB2和T/K比值均显著降低(P<0.01),而6-K则显著升高(P<0.01),各指标也存在着组间差异。结论:患者外周血TXB2、6-K和T/K比值可能参与LIDH发生、发展过程的调控,可作为疾病预后与临床疗效的观察指标之一;局部单穴电针对腰椎间盘突出症具有较好的镇痛作用,其作用机制与改善受累神经根微循环状况有关。 Objective：To detect TXB2 , 6-keto--PGF1α（6-K） and T/K level in plasma of the patients with lumbar intervertebral disc herniation （LIDH ）, so as to probe the potential pathological effect of LIDH, to explore the peripheral analgesic mechanism of electroacupunctur. Methods： All 98 cases of LIDH patients were randomly divided into single- point dectroacupuncture stimulation （SPEAS） treatment group （ n = 53 ） and conventional electroacupuncture stimulation （CEAS） control group （n=45）. The pain content and level of plasma TXB2 , 6-K and T/K before and after treatment were investigated （respectively 9 times and 2 times）. SPEAS and CEAS subjects were treated with the same time, intensity and frequency acupuncture. Results：The results show that the level of plasma TXB2 , and T/K of total LIDH patients are all significantly high than those of normal people （ P〈0.01 ）, however the level of 6-K of the two groups is significantly low than those of normal people （P〈0.01）. After total 8 times treatment, the level of TXB2 ,T/K of the two groups were significantly decreased, at the same time the level of 6-K of the two groups were significantly increased, their are all very closed to the normal （P〈0.05） . However, the changing range of the three effectors of SPEAS group was more significant than those in the CEAS control group （P〈0. 001 ）. Conclusions：The level of TXB2 .6-K and T/K may play an important role in the pathogenesis and development of LIDH. There are significantly correlated with impacts on prognosis and clinical outcome. SPEA is more effective than CEAS in the treatment of LIDH, its analgesic mechanism may be related with the regulation effect of plasma TXB2 , 6-K and T/K level.

关 键 词： 腰椎间盘突出症 单穴电针疗法 血栓素 前列环素

领　　域： [生物学]