机构地区: 衡阳师范学院生命科学系
出 处: 《怀化学院学报》 2006年第2期61-64,共4页
摘 要: 趋化因子受体CCR5与许多人类免疫疾病有关,而CCR5功能的缺失似乎并不会对人体产生很大的影响·通过对CCR5亲和短肽(AFDWTFVPSLIL)的活性分析,发现该短肽能抑制RANTES与PBMCs的结合,也能降低PBMCs对RANTES的趋化作用,并且能抑制RANTES引起的胞内Ca2+的升高,初步认为该短肽可作为CCR5的拮抗剂而受到进一步研究· CCR5 is found to be involved in a broad range of human immune disease and function defeat of CCR5 has not harmful influence to human body, The activity analysis of peptide binding to CCR5 was performed, the results indicated that peptide inhibit the binding of RANTES to PBMCs and suppress chemotactic activity of PBMCs toward RANTES and abrogat the RANTES - induced increase of intracellular Ca^2 + level in PBMCs. So the peptide should be further studied as a CCR5 antagonist.
关 键 词: 趋化因子受体 亲和短肽 外周血单个核细胞 流动 趋化作用
领 域: [生物学]