作　　者： ; ; ; ;

机构地区： 中山大学生命科学学院

出　　处： 《中山大学学报（自然科学版）》 2006年第2期123-125,共3页

摘　　要： 依托GenBank数据库资源,分别对1号、X、Y染色体上CDS区的SNPs分布、类型和密度进行了初步分析。统计结果发现,AG(GA)和CT类型占优,分别各占30%以上;类型AC、AT、GT和CG统计频率在相同的数量级上,分别各占8%左右;并且这种分布频率不会随不同的染色体而变化。但是,SNPs在不同染色体上基因内的分布差异大。SNPs在Y染色体上的密度最小,在1号染色体上的密度最大。一般来说,SNPs的分布位置主要集中在内含子区,但是,在Y染色体上,外显子区的SNPs频数明显升高。 The polymorphisms of CDS regions of the No. 1, X, Y chromosomes of the human genome were analyzed in this paper. The main information was mined, which included the density of the SNPs, the type of the SNPs, and the distribution. There are several possibilities that the SNPs took place, the main situations were that AG （GA） and CT hold the main quantities, above 30%; AC, AT, GT and CG with the same class, hold quantities about 8%. The distribution does not change in different chromosomes. The SNPs were mainly found in the introns, but the SNPs ratio is higher in the exons of chromosome Y than in other chromosomes.

关 键 词： 人类基因组 染色体 多态性

领　　域： [生物学]