作　　者： ; ; ; ; ;

机构地区： 南方医科大学

出　　处： 《中国临床解剖学杂志》 2006年第2期201-203,共3页

摘　　要： 目的:研究外消旋聚乳酸/神经生长因子缓释导管(PDLLA/NGF)的降解性能,为修复神经缺损提供依据。方法:制作PDLLA/NGF缓释导管并用于桥接大鼠坐骨神经缺损,术后1、2、3月分别行导管的大体观察和电镜检查。结果:术后大体观察及电镜检查发现,PDLLA/NGF缓释导管能在大鼠体内随时间延长逐步降解,内层降解比外层速度快,到3月时导管外形仍保持完整,再生神经已顺利通过导管腔,无压迫及疤痕形成。结论:PDLLA/NGF导管在大鼠体内降解时间超过3月,能提供缺损神经再生所需的时间,为神经再生提供良好的微环境。 Objective： To provide basis for PDLLA/NGF controlled release conduit bridging peripheral nerve defect through evaluating the degradation characters of the conduit in vivo. Method： PDLLA/NGF controlled release conduits were manufactured and used to bridge the sciatic nerve defect in rat. Gross observation and electron microscopy were performed at 1 ,2 and 3 month after operation respectively. Results： PDLLA/NGF controlled release conduit gradually biodegraded after the operation. The biodegradation velocity of endothecium was faster than that of exothecium. The conduit retained intact shape and regenerated nerve passed through lumina without compression and scarring within 3 months postoperatively. Conclusion： The degradation time of PDLLA/NGF controlled release conduit exceed 3 months in rats. It could provide enough time for nerve regeneration.

关 键 词： 外消旋聚乳酸 神经生长因子 导管 降解

领　　域： [生物学] [生物学]