作　　者： ; ; ; ;

机构地区： 华南师范大学化学与环境学院

出　　处： 《华南师范大学学报（自然科学版）》 2006年第1期87-91,共5页

摘　　要： 采用溶剂挥发-乳化分散交联法制备利福平/壳聚糖微囊,借助红外光谱仪分析了REP/CS微囊的结构,使用扫描电子显微镜和光学显微镜观测微囊的形态、粒径及分布,紫外分光光度法测定载药量和包封率,考察微囊的体外释药性能,探讨影响制备利福平/壳聚糖微囊的主要因素.结果表明:微囊平均粒径为5.04±2.04μm,成球性良好,搅拌速度和油水比对微囊粒径以及球形影响最大;微囊的包封率达42.67%,主要受壳聚糖质量分数、mCS:mREP的影响;微囊在碱性条件下比在酸性条件下释药较快,具有明显的缓释作用. The rifampicin - loaded chitosan microcapsules were prepared by the solvent evaporation - emulsification cross - linking method. The morphology, particle size and distribution of the microcapsules were observed by scanning electronic microscope and optical microscope. The drug loaded efficiency was surveyed by UV spectrophotometer and in -vitro drug release properties were studied. The results indicated that： the mean particle size was 5.04 ± 2.04 μm; both the stirring speed and the ratio of oil to water can influence particle size. The drug loaded efficiency can reach to 42.7% , while chitosan concentration and the ratio of rifampicin to chitosan were the main effect factors on the drug loaded efficiency. The drug released faster in basic medium than in acid medium with obvious slow -releasing effect.

关 键 词： 壳聚糖 利福平 微囊 药物释放

领　　域： [理学] [理学]