作　　者： ; ; ;

机构地区： 四川农业大学动物科技学院

出　　处： 《畜牧兽医学报》 2006年第2期183-186,共4页

摘　　要： 为研究桔梗对左氧氟沙星(LVLX)在健康鸡体内的血药浓度及药动学参数的影响,72只健康鸡随机平均分成2组,Ⅰ组单剂量灌胃给予左氧氟沙星(10 mg/kg);Ⅱ组左氧氟沙星(10 mg/kg)与桔梗煎液(2 g/kg)联用。采用高效液相色谱法测定血药浓度,最低检测限0.001 mg/L,并以3P97药动学程序进行分析,药时数据均符合一级吸收二室模型(权重=1)。与Ⅰ组相比,Ⅱ组的药动学参数有如下变化:T1/2α、T1/2ka增大,Cmax、ka降低,差异均不显著(P>0.05);T1/2β、Tmax、AUC、MRT0-36均极显著增加(P<0.01)。结果表明:桔梗对左氧氟沙星在健康鸡体内的药物代谢有较大影响;减慢LVLX在体内的吸收速度,但增加了LVLX吸收的程度;加快了LVLX向组织的转运;减慢了LVLX在鸡体内的消除速度,延长了药物在体内的作用时间。 Effect of Chinese herb Platycodon grandiflorum on pharmacokinetic variance of levofloxacin was studied in chickens. 72 healthy chickens were allocated into two groups of 36 chickens each. The chickens in group I were orally given single dose of levofloxacin at 10 mg/kg, the chickens in group Ⅱ were orally given single dose of levofloxacin at 10 mg/kg and Platycodon grandiflorum at 2 g/kg simultaneously. The concentrations of levofloxacin in plasma were deter mined by high performance liquid chromatography with a limit of detection of 0. 001 mg/L. The pharmacokinetic data were calculated by 3P97 PK program and fitted a two compartment model with 1 st order absorption（weight= 1）. The main pharmacokinetics parameters in chickens were as follows, respectively, group Ⅰ： T1/2Ka = （0. 815 ± 0. 043） h, T1/2α = （1. 267 ± 0. 029 ） h, T1/2β = （3.492±0.352）h,Tmax=（1.624±0.073）h,C =（1. 715±0.106）mg/L,AUC=（9.470±0.690） mg/（L · h） ,Ka= （0. 852±0. 046）h^-1 , MRT0-36= （4. 759±0. 017）h;group Ⅱ ： T1/2Ka = （1. 027± 0. 137）h, T1/2α = （1. 696 ± 0. 383） h, T1/2β= （9. 238± 1. 170） h, Tmax= （2. 034 ± 0. 020） h, Cmax = （1. 631±0. 022）mg/L,AUC=（13. 025±0. 301）mg/（L · h）,Ka= （0. 684±0. 099）h^-1,MRT0-36 （7. 154±0. 084）h. The results showed that Platycodon grandiflorum could influence the pharmacokinetic parameters of levofloxacin in healthy chickens significantly, the influence include decreasing the speed of absorption, enhancing the degree of absorption, accelerating the distribution from blood to tissue, retarding the speed of elimination and lengthening the time of drug action.

关 键 词： 左氧氟沙星 桔梗 药动学 鸡 高效液相色谱法

领　　域： [农业科学] [农业科学] [农业科学]