作　　者： ; ;

机构地区： 广东省实验动物监测所

出　　处： 《中国比较医学杂志》 2006年第1期45-48,共4页

摘　　要： 许多种类的动物都被用于结核病的研究,每一种动物都有其优缺点,非人灵长类对结核分枝杆菌易感,通过气溶胶途径感染能发展成类似人类的疾病,包括肺的病变,疾病的不同进展过程,以及免疫特征。在体内和体外能表现T淋巴细胞的增殖反应,能通过接种BCG疫苗获得保护。因此,非人灵长类感染结核病的感染模型在研究结核病感染和免疫,探讨结核病感染过程中,结核菌是怎样摧毁机体的免疫系统;在评价肺结核病疫苗的有效性方面,是许多常规动物模型所不可替代的。然而,目前世界上对于结核病感染非人灵长类动物模型的研究报道较少,可利用的数据也缺乏,先进的免疫学技术还很少应用于结核病感染非人灵长类动物模型,严重限制了结核病的研究进展。因此,建立非人灵长类结核病模型,是目前人类结核病研究势在必行。 A viariety of animals have been used for tuberculosis research, anti each animal model has its own strong anti weak points. Nonhuman primates are quite susceptible to Mycobactcrium tuberculosis infection by aerosol route and to develop a disease resembling to that in humans, including the pathology in the lungs, the progression of tile disease, the characteristics of immunologic alterations, the antigen-induced T lymphocyte reactivity both in vitro and in vivo, and get to be protected by BC（; vaccination. Therefore, nonhuman primates seem to have significant advantages over conventional laboratory animals in the research on the relation to irffeetion and immunology, and the process of immunologic system devastation. Also such model is valuable in evaluation of effectiveness of vaccines. But there were limited published data available on nonhuman primate tuberculosis. Modern immunological techniques have not yet been well applied to the research of nonhuman primate tuberculosis. This fact hampered the progress of tuberculosis research considerably. It is of great importance to develop nonhuman primate tuberculosis models to serve human tuberculosis research.

关 键 词： 非人灵长类 结核病 模型 动物 免疫 疫苗

领　　域： [农业科学] [农业科学]