作　　者： ; ; ; ; (梁松林）;

机构地区： 河南农业大学

出　　处： 《中国兽药杂志》 2006年第2期31-34,共4页

摘　　要： 用改进的试管两倍稀释法测定了黄连、鱼腥草、大青叶和苦参4味中药及其相互配伍（1：1）对标准大肠杆菌的最小抑菌浓度和4味中药与抗菌药配伍（1000：1）对临床分离鸡大肠杆菌的最小抑菌浓度。结果表明，4味中药及其相互配伍对大肠杆菌标准株有一定的抑制作用，其MIC值介于3．91—62．50mg／mL之间，其中大青叶和鱼腥草以1：l配伍对大肠杆菌抑菌效果最好，MIC为3．91mg／mL；对临床分离株，单方药中黄连抑菌效果最好，MIC为31．25mg／mL，24种复方药中，黄连和盐酸多西环素或加替沙星以1000：1配伍的抑菌效果最好，其MIC为3．91mg／mL。 In this paper, 4 kinds of Chinese traditional medicine and their compounds＇ MICs against standard E. coli and the MICs against clinical E. coli of the combinants with antibiotics（ 1 000：1 ）were tested by the ameliorative two fold dilution method. The results indicated that 4 kinds of Chinese traditional medicine and their combinations all had certain inhibital effect against E. coli, their MICs were between 3.91 and 62.50 mg/mL, the combination of prunusmume leaf and chordate houttuynia had the best inhibital effect against E. coli , its MIC was 3.91 mg/mL. Coptis inhibital effect was the best against clinical E. coli, its MIC was 31.25 mg/mL. Among the 24 kinds of combinations drugs, the combination of coptis with doxycycline or with amikacin（ 1 000：1 ）had the best inhibital effect on bacteria, the MICs were 3.91 mg/mL respectively.

关 键 词： 中药 复方 大肠杆菌 最小抑菌浓度

领　　域： [农业科学] [农业科学] [农业科学]