作　　者： ; ; ; ; (陈杖榴）;

机构地区： 华南农业大学动物科学学院

出　　处： 《家畜生态学报》 2005年第5期76-79,共4页

摘　　要： 本文测定了恩诺沙星的水溶解度和正辛醇／水分配系数,为其生态风险评价提供参 数。结果表明,采用《中华人民共和国药典》中规定的测定药物溶解度的方法、摇瓶法和振荡法 测得25℃时恩诺沙星的水中溶解度分别为161．33mg／L、243．28mg／L、202．56mg／L,说明恩 诺沙星属于难溶于水的化合物。3种方法中,药典法测定费时短,但结果偏低;振荡法和摇瓶法 测定所需时间较长,但结果较为准确。采用摇瓶法测得25℃时,思诺沙星的正辛醇／水分配系 数为4．45,说明恩诺沙星有一定程度的亲脂性,较易在生物体内富集。 So The text determined the water solubility and the n-octanol-water partition coefficient of enrofloxacin. It would provide parameter for the ecological risk assessment of enrofloxacin. The results indicated. Solubility of enrofloxacin in water at 25℃ was determined by three methods as the method prescribed in《Pharmacopoeia of People＇s Republic of China》, the flask-shaking method and the shaking method. The solubility of Enrofloxacin in water was 161. 33mg/L, 243. 28mg/L and 202. 56mg/L, respectively. According to the standard, Enrofloxacin was a chemical difficult to dissolve. Of.three methods, the method prescribed in pharmacopoeia need the shorter time, but the result was lower; the other two methods need more time, but the results were more accurate. The n-octanol-water partition coefficient of Enrofloxacin at 25℃ determined by flask-shaking method was 4. 45. This indicated that Enrofloxacin was a lipophilic chemical and was enriched by organism easily.

关 键 词： 恩诺沙星 水溶解度 正辛醇 水分配系数

领　　域： [农业科学] [农业科学]