作　　者： ; ; ; ;

机构地区： 中山大学化学与化学工程学院

出　　处： 《化学研究与应用》 2005年第6期790-792,共3页

摘　　要： Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-trihydroxyoctadecane(A) and γ-stearolactone(B).In the primary bioassay,compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ,and also had no significant inhibitory activity to tumor cell lines Bel-7402 and NCIH-460.It was the first report that γ-stearolactone(B) isolated from marine fungus as natural product. Two metabolites（ A and B） were isolated from a mangrove endophytic fungus Stysanus like sp. （#2492） from the South China Sea. Their structures were elucidated by spectral data as N - （2＇ - hydroxytetracosyl） -2 - amino - 1,3,4 - trihydroxyoctadecane （A） and γ-stearolactone （B）. In the primary bioassay, compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ , and also had no significant inhibitory activity to tumor cell lines Bel - 7402 and NCIH - 460. It was the first report that γ - stearolactone （B） isolated from marine fungus as natural product.

关 键 词： 海洋真菌 代谢产物 羟甲基 二羟基 十七烷基 羟基二十四碳酰胺 硬脂酸内酯 生理活性

领　　域： [理学] [理学]