作　　者： ; ; ;

机构地区： 湘潭大学化学学院

出　　处： 《应用化学》 2005年第10期1158-1160,共3页

摘　　要： The condensation reaction of 4-hydroxycoumarin with each of ah substituted benzalacetones in（absolute） ethanol gave coumarin analogues which were subsequently converted to their ethyl ethers（cyclocou-（marin））.The ethers can be quantitatively converted back to the coumarin analogues by acid hydrolysis.Four of them are new substances.The reaction mechanism is discussed in detail.All the products were characterized by HPLC,IR and 1H NMR.Compared with the present process in the literature,the process for the synthesis of the coumarin analogues is obviously improved on the reaction time,temperature,solvent,（catalyst）,and post-treatment. The condensation reaction of 4-hydroxycoumarin with each of a-h substituted benzalacetones in absolute ethanol gave coumarin analogues which were subsequently converted to their ethyl ethers （cyclocoumatin）. The ethers can be quantitatively converted back to the coumarin analogues by acid hydrolysis. Four of them are new substances. The reaction mechanism is discussed in detail. All the products were characterized by HPLC, IR and ^1H NMR. Compared with the present process in the literature, the process for the synthesis of the coumarin analogues is obviously improved on the reaction time, temperature, solvent, catalyst, and post-treatment.

关 键 词： 羟基香豆素 取代苯丁烯酮 缩合 香豆素类似物

领　　域： [理学] [理学]