作　　者： ; ; ;

机构地区： 四川农业大学

出　　处： 《畜牧兽医学报》 2005年第7期727-731,共5页

摘　　要： 15头健康仔猪,分3组,每组5头:即健康组、脾虚组和四君子汤反证组。按20mg/kg的剂量内服进行左旋氧氟沙星的辨证药动学研究。高效液相色谱法测定血浆中药物浓度,3p97药代动力学程序处理药时数据。健康组和脾虚组药动学数据符合一级吸收一室模型,四君子汤反证组药动学数据符合一级吸收二室模型。试验结果表明:仔猪脾虚状态下明显影响左旋氧氟沙星内服给药的药动学特征(PK);四君子汤可使脾虚仔猪异常的左旋氧氟沙星的药动学特征得到恢复,为验证“辨证药动学”假说和完善中西兽医结合提供了进一步的科学依据。 Fifteen healthy piglets were distributed into three groups randomly: healthy group, spleen deficiency group, sijunzi decoction antisyndrome group, five piglets each. The study on “pharmacokinetics of syndrome differentiation” was carried out after a single oral administration of levofloxacin(20 mg/kg B.W.) in piglets. The levofloxacin concertration in plasma was detected with HPLC, calculation of pharmacokinetics parameters was performed using 3p97 PK programe, further pharmacokinetics analysis was performed using SPSS(12.0) statistic software. The datas of the drug concentration-time in the two groups of the healthy group, spleen deficiency group were fitted to a one-compartment model with first-order absorption, the counterparters of sijunzi decoction antisyndrome group were in line with a two-compartment with first-order absorption. The results indicated that the spleen deficiency condition of the piglets influenced the PK of levofloxacin; sijunzi decoction could resume the characteristics of the PK parameters in spleen deficiency condition, which also provided scientific evidence for the hypothesis of “pharmacokinetics of syndrome differentiation”, also for the better combination between the west animal medicine and Chinese traditional animal medicine.

关 键 词： 仔猪 脾虚 辨证药动学 左旋氧氟沙星 四君子汤

领　　域： [农业科学] [农业科学] [农业科学]