作　　者： ; ; ; ; ; ;

机构地区： 中山大学生命科学学院

出　　处： 《高分子材料科学与工程》 2005年第3期77-80,共4页

摘　　要： 采用熔融聚合法直接合成生物降解材料聚乳酸-乙醇酸(PLGA),并以其为载体制备基因重组人干扰素聚乳酸-乙醇酸微球(IFN-α-PLGA-MS)。通过正交试验对干扰素微球的制备工艺进行了优选,同时对微球的性质进行了考察。结果以D,L-乳酸、乙醇酸为原料,氯化亚锡(SnCl2)为催化剂,在165℃、70Pa下熔融聚合10h,PLGA特性粘数[η]最高可达0.2382dL/g,干扰素微球的形态圆整,平均粒径为10.71μm,药物确已被包裹在微球中,微球载药量和包封率分别为8.06%、36.97%,且获得了较满意的干扰素微球制备工艺。 Biodegradable material poly (lactic acid-glycolic acid) (PLGA) was directly synthesized via melt polycondensation. The poly (lactic acid-glycolic acid) synthesized was applied in Interferon-α microspheres. The optimal conditions for the preparation of Interferon-α microspheres were determined with orthogonal test. The characters of microspheres were examined. Starting from D,L-lactic acid and glycolic acid, catalyzed by SnCl_2, under 165 ℃ and 70 Pa, PLGA with the highest intrinsic viscosity (0.2382) dL/g was produced. Microspheres formed are spherical with smooth surfaces. The average particle size is (10.71) μm. Drug is enveloped in microspheres without mixing physically with PLA. The drug loading and the encapsulation efficiency of Interferon-α microspheres is (8.06%) and (36.97%) respectively. Interferon-α PLGA microspheres were successfully prepared.

关 键 词： 聚乳酸 乙醇酸 直接熔融聚合 制备 干扰素 微球

领　　域： [一般工业技术]