作　　者： ; ; (洪好武）;

机构地区： 广东医学院

出　　处： 《天津药学》 2005年第1期1-3,共3页

摘　　要： 目的 :探讨意苡仁酯两种微胶囊化的方法及其工艺条件 ,选出能制备高质量微胶囊产品的较好方法 ,并确定其最佳工艺条件。方法 :以丙酮为溶剂提取薏苡仁酯 ,分别采用锐孔 -凝固浴法和喷雾干燥法制备薏苡仁酯微胶囊。结果 :锐孔 -凝固浴法最佳工艺条件为壁材海藻酸钠初始溶液的质量浓度为 10 g/ L,芯材薏苡仁酯与壁材海藻酸钠的质量之比为 0 .6∶ 1,乳化剂在壁材与芯材乳化分散液中的质量浓度为单甘酯 0 .5 g/ L、蔗糖酯 0 .5 g/ L,乳化温度 5 0～ 6 0 o C,固化液Ca Cl2 的质量浓度为 10 g/ L。喷雾干燥法最佳工艺条件为海藻酸钠的质量浓度 15 g/ L,薏苡仁酯与海藻酸钠的质量之比1∶ 1,乳化剂的质量浓度为单甘酯 0 .5 g/ L,蔗糖酯 0 .5 g/ L,乳化温度 6 0～ 70 o C。结论 :用喷雾干燥法制备得到的薏苡仁酯微胶囊包埋率较高 ,感官质量较好 ,保存效果较长。 Object: To study the methods for the microencapsulation of coixendide and select the better method and optimal technology. Methods: Coixendide was extracted by acetone from coix. Coixendide was microencapsulationed by piercing-solidifying incuber method and spray drying method, respectively. Results: In both methods, sodium alginate as wall-material was 10 g/L and 15 g/L respectively; the concentration of emulsifier MG and SE both was 0.5 g/L; the ratio of coixendide to sodium alginate was 0.6∶1 and 1∶1 respectively; the emulsification temperature was 50～60 oC and 60～70 oC respectively. The concentration of CaCl_2 solation was 10 g/L in the piercing-solidifying incuber method. Conclusion: The retention ration of coixendide microcapsules from spray drying method was higher than from piercing-solidifying incuber method and the former preparation could be preserved longer.

关 键 词： 薏苡仁酯 锐孔 凝固 喷雾干燥 微胶囊

领　　域： [化学工程]