作　　者： ; ; ; ; ; ;

机构地区： 中国科学院大连化学物理研究所

出　　处： 《物理化学学报》 2005年第1期1-5,共5页

摘　　要： 在80～370K 温度范围内，用精密自动绝热量热计准确测量了右旋布洛芬的摩尔热容．其固态右旋布洛芬测量值对折和温度 X[X=f(T)]的拟和方程为：C_(p，m(s))=-39.483X^4-66.649X^3+95.196X^2+210.84X+172.98；相应的液态的拟和方程为：C_(p，m(L))=7.191X^3+4.2774X^2+56.365X+498.5．并计算得到右旋布洛芬相对于室温(298.15K)的摩尔焓和摩尔熵，右旋布洛芬的熔点为(324.15±0.02)K．基于摩尔热容的测量，还可获得右旋布洛芬的纯度为99.44%，并对右旋布洛芬和消旋布洛芬的热容进行了对比研究。 Molar heat capacities of ( S)-ibuprofen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 370 K. Experimental heat capacities were fitted into a polynomial equation of heat capacities ( C-p,C- m) with reduced temperature ( X), [ X = f(T)]. The polynomial equations for ( S)-ibuprofen were C-p,C- m(s) = - 39.483 X-4 - 66. 649 X-3 + 95. 196 X-2 + 210. 84 X + 172. 98 in solid state and C-p,C- m(L) = 7. 191X(3) + 4. 2774 X-2 + 56. 365 X + 498. 5 in liquid state. The thermodynamic functions relative to the reference temperature of 298. 15 K, H-T - H-298.15 and S-T - S-298.15, were derived for the( S)-ibuprofen. A fusion transition at T-m = (324. 15 +/- 0. 02) K was found from the C-p - T curve. The molar enthalpy and entropy of the fusion transition were determined to be (18. 05 +/- 0. 31) kJ.mol(-1) and (55. 71 +/- 0. 95) J.mol(-1).K-1, respectively. The purity of the ( S)-ibuprofen was determined to be 99. 44% on the basis of the heat capacity measurement. Finally, the heat capacities of ( S)-ibuprofen and racemic ibuprofen were compared.

关 键 词： 右旋布洛芬 绝热量热 热容

领　　域： [理学] [理学]