作　　者： ; ; ; ; ;

机构地区： 江苏大学临床医学院

出　　处： 《江苏大学学报（医学版）》 2004年第416期485-488,共4页

摘　　要： 目的观察运动情况下组织器官游离铁(FI)代谢和贮存铁(SI)的变化及其与非血红素铁(NHI)的关系。方法SD大鼠分为运动组(EG)和静息组(SG);EG游泳3个月后分析两组肝脏、脾脏、肾脏、心脏和骨髓细胞NHI和FI含量,计算SI和SI/FI的比率。结果与SG比较,EG的运动显著降低肝脏NHI和FI含量,减少SI含量,升高SI/FI比率;显著降低脾脏和骨髓细胞NHI含量,升高FI含量,减少SI含量,降低SI/FI比率;显著增加肾脏NHI含量和FI含量,增加SI含量,降低SI/FI比率;显著增加心脏FI含量,维持SI含量,降低SI/FI比率。结论长期运动导致组织细胞FI代谢和SI发生变化,但不同组织之间发生行为分化;运动导致不同组织细胞SI与FI之间的铁转移,在组间比较或不同组织之间应用NHI比较SI时要考虑FI的变化。 Objective: This study was to observe the changes of free iron (FI) metabolism and storage iron (SI) and their relation to the changes of non-heme iron (NHI) contents under the long-term exercise condition. Methods: The SD Rats were divided into the exercise group (EG) and the sedentary group (SG). After 3 months of swimming in EG, the liver, kidney, heart and bone marrow cells in both groups were isolated and their contents of FI and NHI were analyzed, and then storage iron (SI) and SI/MHI were calculated. Results: Compared with SG, the liver in EG had the significantly decreased NHI and FI contents as well as the decreased SI contents and the increased SI/FI ratio; the spleen and bone marrow cells had the significantly decreased NHI contents and increased FI contents as well as the decreased SI contents and SI/FI ratio; the kidney had the significantly increased NHI and FI contents as well as the increased SI contents and the deceased SI/FI ratio; the heart had the significantly increased FI contents with the decreased SI/FI ratio and maintained SI contents. Conclusion: Long-term exercise resulted in the changes of FI metabolism and SI contents with a differential behavior in the different organs due to the transfer between SI and FI pool. The comparison of NHI contents between the groups or among the different tissues may not indirectly reflect the changes of SI contents. [

关 键 词： 运动 铁贮存 游离铁

领　　域： [生物学] [生物学]