作　　者： ; (金欣）; (贾卫民）;

机构地区： 涌泉集团有限公司博士后工作站福建厦门361023

出　　处： 《现代化工》 2004年第8期42-44,共3页

摘　　要： 采用重氮乙酸乙酯(EDA)与乳酸乙酯在二水杨醛铜(Ⅱ)催化下进行O—H插入反应合成了香料呋喃酮前体化合物α-甲基-缩二乙醇酸二乙酯。讨论了催化剂、反应温度和物料比例对插入反应收率的影响,在优化反应条件下产率为69%。与原工艺采用的Williamson反应相比,反应收率提高10%,产品纯度大于98%,而反应条件更温和。 Ethyl diazoacetate (EDA) undergoes a facile bis (salicylaldehydato) copper (Ⅱ) carbenoid mediated O-H insertion reaction with ethyl lactate to afford the title compound.The title compound was used as a synthetic precursor for flavor:2,5-dimethyl-4-hydroxyl-3(2H)-furanone.The effects of catalyst,reaction temperature as well as the ratio of ethyl lactate and EDA on the insertion yield were discussed.Under optimized reaction conditions the title compound was obtained to be a 69% yield.The yield of this novel process is 10% higher than that of classical Williamson reaction.The purity of product is over 98%.The mild reaction conditions are more satisfactory than Williamson reaction.

关 键 词： 甲基 缩二乙醇酸二乙酯 卡宾 插入反应

领　　域： [化学工程]