作　　者： ; ; ; ;

机构地区： 广东省实验动物监测所

出　　处： 《中国实验动物学报》 2005年第S1期59-60,共2页

摘　　要： [目的]观察禽流感H5N1型病毒对沙鼠的致病性;[方法]在生物安全三级实验室,将禽流感H5N1型病毒通过滴鼻接种乙醚麻醉后沙鼠,观察14天,记录沙鼠的体温体重、临床症状、病理变化、病毒分离及抗体变化;[结果]沙鼠感染后发病主要表现在第2天至第6天,攻毒组沙鼠出现反应迟钝、皱毛、弓背、食欲下降、呼吸急促、打堆等症状,攻毒组沙鼠的体温降低和体重减轻,死亡率为44%,在第8天检出抗体,主要病理变化表现为肺出现严重淤血、水肿、出血,镜下可见肺间质充血,血管周围炎性细胞浸润,肝和胸腺淤血,肾出血,肾小管变形。 To investigate the pathogenicity of avian influenza virus in Gerbil Anesthetized gerbils were inoculated with avian influenza virus in biosafety level 3 laboratory. Fourteen days after inoculation,clinical signs were observed and the blood samples were collected to analyze abti-AIV antibody. Tissue samples from lungs, livers, and kidneys were used to virus isolation and histopathology. Result showed that the H5N1 AIV caused severe disease in gerbils mainly between day 2.p.i ang 6.p.i, which characterized by...

关 键 词： 沙鼠 禽流感 型病毒 致病性

领　　域： [农业科学] [农业科学] [农业科学]