作　　者： ; ; ; ; ; ; ;

机构地区： 广东省实验动物监测所

出　　处： 《中国实验动物学报》 2005年第S1期56-57,共2页

摘　　要： [目的]Balb/c小鼠通过尾静脉注射和鼻腔接种禽流感H5N1亚型病毒造疾病模型,观察其血细胞变化。[方法]以禽流感H5N1亚型病毒通过静脉和鼻腔接种Balb/c小鼠,分别在0~7天和0~11天取血进行血细胞计数和分类,同时对于静脉接种方法进行了0~8小时的短时间监控。[结果]静脉接种途径在接种病毒后2小时就能显著的降低小鼠的白细胞总数、粒细胞及淋巴细胞数,白细胞总数及淋巴细胞数在第3天、粒细胞数在第2天就恢复正常而后均显著升高;而鼻腔接种仅在1~3天淋巴细胞有所降低,而后恢复正常;1~6天白细胞总数及粒细胞数显著升高,而后恢复正常。[结论]从血细胞变化而言,静脉接种相比鼻腔接种方法要好。 [Objective] Balb/c mouse was infected with Influenza A (H5N1) viruses by inoculation intranasally and tail vein and the changing of blood cells was detected. [Methods] Balb/c mouse was infected with Influenza A (H5N1) viruses by inoculation intranasally and tail vein. The blood samples were collected and cells were counted and classified in 0～7day and 0～11 day with a steak observation after 0～8 hours tail vein inoculation. [Results] inoculation of influenza A (H5N1) viruses through tail vein decreased leuco...

领　　域： [农业科学] [农业科学] [农业科学]